Research and Education | Osaka University, International Center for Biotechnology

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Cooperative Research Station (CRS)
Cooperative Research Station (CRS)
Fujiyama Lab
Honda Lab
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Research and Education
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Research and Education

Exploration and Application of Unique Microorganisms and Their Biomolecules

We are focusing on novel microorganisms with unique physiology in tropical area and investigating the function of their biomolecules (genes and enzymes). We are also engaged in the utilization of these biomolecules as building blocks to develop novel biotechnological systems. Owing to great diversities in their natural environments, Southeast Asian countries are expected to be rich in biological recourses. We aim at pioneering new frontier of applied microbiology thorough a tight collaboration with researchers in these countries.
Research topics
  1. Exploration of novel microorganisms with unique physiology and biochemical characterization of their genes and enzymes
  2. Application of unique biomolecules in the development of novel biotechnological systems
  3. Screening for actinomycetes producing novel secondary metabolites
  4. Elucidation of biosynthetic pathways of secondary metabolites in actinomycetes and their regulatory mechanisms
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Bio-conversion and Process Engineering of Biological Resources

Research projects involve development of new bio-conversion processes for tropical natural resources, development and improvement in designs of bioreactors by process-system-engineering approaches, and the development of purification system for the products from biological processes.
Research topics
  1. Cultivation of marine microalgae for fuel oil production.
  2. Control of bone marrow cell culture.
  3. Pharmaceutical production and glyco-engineering.

[Pictures of marine microalgae cultivation ]

[Figure about bone marrow cell culture]

[Figure about glyco-engineering]
 
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Conservation of Biological Resources

With the emphasis on the development of sustainable utilization of biological resources on earth, particularly the microorganisms of industrial importance, the researches are focused on the search for new microbial resources and their applications, and the investigation of gene transfer among microorganisms. The approach employed is through the studies on molecular phylogenic classification of industrial microorganisms, e.g. actinomycetes, and of microorganisms important for the preservation of natural environment, e.g. nitrogen-fixing bacteria and photosynthetic bacteria, and the development of a rapid identification method for the microorganisms.
Nodule of legume plant
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Post-Graduate Course

ICBiotech is involved in the education activities of Department of Biotechnology, Graduate School of Engineering as collaborating laboratories and currently covers several fields of biotechnology in education and research.

Applied microbiology laboratory (chaired by Prof. Kazuhito FUJIYAMA)

Research topics ]
  1. Taxonomic study and classification of phototrophic bacteria, nitrogen-fixing nodule forming bacteria, and ascomycetous yeast
  2. Molecular phylogeny and molecular evolution of bacteria
  3. Study of microbial diversity in the tropical area
  4. Production of human glycoprotein in plant cells, modifying the glycan-processing pathway
  5. Production of biologically active substances by molecular breeding of microbes and plants

Molecular microbiology laboratory (chaired by Prof. Kohsuke HONDA)

Research topics ]
  1. Construction of an in vitro artificial metabolic pathway using thermophilic enzymes and its application to chemical manufacturing
  2. Development of novel technology to control structure and function of microbiota
  3. Exploration of novel secondary metabolites produced by actinomycetes and elucidation of their biosynthetic pathways
  4. Elucidation of regulatory mechanisms of secondary metabolites biosynthesis in actinomycetes and unmasking their cryptic metabolites
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