Research and Education | Osaka University, International Center for Biotechnology

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Lab of Molecular Microbiology
Fujiyama Lab
Cooperative Research Station (CRS)
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Research and Education

Research and Education

Discovery of New Functions from Biological Resources

Research projects focus on the screening and analysis of novel biological functions from various microorganisms and plant cells in tropical area, in parallel with the development of useful functions by metabolic/molecular engineering, and the development and application of biological functions of mammalian cells, organelle, etc., by cell and tissue engineering.
Research topics
  1. Analysis on the biosynthetic regulation mechanism in actinomycetes producing antibiotics and/or immunosuppressant.
  2. Analysis on the biosynthesis and regulation pathway for food colorant and hypocholesteroleimc drug in fungi.
  3. Development of defense methods against plant pathogenic bacteria.
  4. Screening of new bioactive compounds from Entomopathogenic fungi.
  5. Production of bioactive compounds derived from lactic acid bacteria.

Bio-conversion and Process Engineering of Biological Resources

Research projects involve development of new bio-conversion processes for tropical natural resources, development and improvement in designs of bioreactors by process-system-engineering approaches, and the development of purification system for the products from biological processes.
Research topics
  1. Cultivation of marine microalgae for fuel oil production.
  2. Control of bone marrow cell culture.
  3. Pharmaceutical production and glyco-engineering.

[Pictures of marine microalgae cultivation ]

[Figure about bone marrow cell culture]

[Figure about glyco-engineering]

Conservation of Biological Resources

With the emphasis on the development of sustainable utilization of biological resources on earth, particularly the microorganisms of industrial importance, the researches are focused on the search for new microbial resources and their applications, and the investigation of gene transfer among microorganisms. The approach employed is through the studies on molecular phylogenic classification of industrial microorganisms, e.g. actinomycetes, and of microorganisms important for the preservation of natural environment, e.g. nitrogen-fixing bacteria and photosynthetic bacteria, and the development of a rapid identification method for the microorganisms.
Nodule of legume plant

Post-Graduate Course

ICBiotech is involved in the education activities of Department of Biotechnology, Graduate School of Engineering as collaborating laboratories and currently covers several fields of biotechnology in education and research.

Applied microbiology laboratory chaired (by Prof. Kazuhito Fujiyama)

Research topics ]
  1. Taxonomic study and classification of phototrophic bacteria, nitrogen-fixing nodule forming bacteria, and ascomycetous yeast
  2. Molecular phylogeny and molecular evolution of bacteria
  3. Study of microbial diversity in the tropical area
  4. Production of human glycoprotein in plant cells, modifying the glycan-processing pathway
  5. Production of biologically active substances by molecular breeding of microbes and plants

Molecular microbiology laboratory chaired (by Prof. Takuya Nihira)

Research topics ]
  1. Screening of new bioactive compounds from microorganisms
  2. Molecular genetic study on symbiotic systems
  3. g-Butyrolactone autoregulator-dependent regulation mechanism in Streptomyces
  4. Regulation mechanism of secondary metabolism in actinomycetes
  5. Biosynthesis and regulation pathway for bioactive compounds in fungi
  6. Process control on proliferation and differentiation of primary human cells
  7. Genetic engineering design of animal cells for medical use

Streptomyces Hormone
Virginiae Butanolide A